Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia

作者：Cordeiro Farias Isabela Cristina; Mendonca Belmont Taciana Furtado; da Silva Andreia Soares; do O Kleyton Palmeira; Ferreira Felipe; Medeiros Fernanda Silva; da Silva Vasconcelos Luydson Richardson; Cavalcanti Bezerra Marcos Andre; Araujo Aderson da Silva; Mendes Freire de Moura Patricia Muniz; Domingues Hatzlhofer Betania Lucena; Mendonca dos Anjos Ana Claudia; de Mendonca Cavalcanti Maria do Socorro

来源：Mediterranean Journal of Hematology and Infectious Diseases, 2018, 10(1): e2018012.

DOI：10.4084/MJHID.2018.012

• Sickle Cell Anemia
• MnSOD
• Vaso-occlusive events

The SOD2 polymorphism Val16Ala T -> C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS.

• 出版日期2018-2-21