A series of novel complexes firstly constructed by 1,4-phenylenedioxydiacetic acid plays a role in disruption of DNA gene expression and induction of apoptosis

作者：Zhu, Mingchang; Peng, Tingting; Sun, Na; Qiu, Xue; Zhan, Yang; Ding, Yuqing; Zhang, Shaozhong; Gao, Enjun^*

来源：Journal of Inorganic Biochemistry, 2018, 180: 141-154.

DOI：10.1016/j.jinorgbio.2017.11.007

• DNA binding
• Apoptotic
• Crystal structure
• Molecular docking

A set of five metal organic frameworks, namely, [Cd-2(L)(2)BIP(H2O)(2)center dot 6H(2)O](n) (1), [Ce(L)(1.5)(H2O)(2)center dot H2O](n) (2), [Sm(L)(1.5)(H2O)(2)center dot 3H(2)O](n) (3), [Gd(L)(1.5)(H2O)(2)center dot 3H(2)O](n) (4), [Ho(L)(1.5)(H2O)(2)center dot 3H(2)O](n) (5), have been prepared under hydrothermal conditions (1,4-H2L =1,4-Pheny lenedioxydiacetic acid; 1,4-BIP = 1,4-bis(2-pyridylmethyl) piperazi-ne; C2H5OH = EtOH). The long BIP ligand (N...N separation of ca. 8.355 angstrom) induces interpenetration of 1 to increase both the framework stability and the density of effective catalytic metal centers. Characterization of all complexes has been carried out by means of IR spectroscopy, single crystal and powdered sample X-ray diffraction (PXRD) through conventional and synchrotron radiation, Thermogravimetric (TG), fluorescent measurement (liquid and solid), DNA molecular docking, cancer cell apoptosis morphology through fluorescent inverted microscope, ICso, which the cytotoxic activity of the complexes was tested against two different cancer and one normal cell lines. The results indicate that all the complexes are potential fluorescent light-emitting materials and the flour (2, 3, 4, 5) complexes present remarkable anti-cancer effect.

• 出版日期2018-3
• 单位沈阳化工大学