Dietary Lutein Modulates Growth and Survival Genes in Prostate Cancer Cells

作者：Rafi Mohamed M; Kanakasabai Saravanan; Gokarn Sarita V; Krueger Eric G; Bright John J^*

来源：Journal of Medicinal Food, 2015, 18(2): 173-181.

DOI：10.1089/jmf.2014.0003

• cancer prevention
• PC-3 cells
• carotenoids
• prostate cancer
• lutein

Lutein is a carotenoid pigment present in fruits and vegetables that has anti-inflammatory and antitumor properties. In this study, we examined the effect of lutein on proliferation and survival-associated genes in prostate cancer (PC-3) cells. We found that in vitro culture of PC-3 cells with lutein induced mild decrease in proliferation that improved in combination treatment with peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists and other chemotherapeutic agents. Flow cytometry analyses showed that lutein improved drug-induced cell cycle arrest and apoptosis in prostate cancer. Gene array and quantitative reverse transcription-polymerase chain reaction analyses showed that lutein altered the expression of growth and apoptosis-associated biomarker genes in PC-3 cells. These findings highlight that lutein modulates the expression of growth and survival-associated genes in prostate cancer cells.

• 出版日期2015-2-1
• 单位rutgers