Anti-obesity effects of traditional and standardized meju in high-fat diet-induced obese C57BL/6J mice

作者：Bae Cho Rong; Kwon Dae Young; Cha Youn Soo^*

来源：Journal of Clinical Biochemistry and Nutrition, 2014, 54(1): 45-50.

DOI：10.3164/jcbn.13-52

• meju
• high fat diet
• lipid metabolism
• C57BL/6J mice
• anti-obesity

The aim of the study was to evaluate the anti-obesity effects of two types of meju in diet induced obese C5761/6J mice. Animals were randomly divided into 4 dietary group (n = 10); normal diet high fat diet with 30% soybean, high fat diet with 30% traditional meju, high fat diet with 30% standardized meju. After 16 weeks, after animals were sacrificed. It was observed that the high fat diet with 30% traditional meju and high fat diet with 30% standardized meju significantly reduced body weight gain, epididymal fat weight serum triglyceride along with serum insulin and leptin levels compared to the high fat diet with 30% soybean. And also, the expression levels of hepatic lipid anabolic genes were significantly decreased in the high fat diet with 30% traditional meju and high fat diet with 30% standardized meju compared to the high fat diet with 30% soybean. In conclusion, the assessment of all the obesity markers strongly advocate the anti-obesity effect of traditional as well as standardized meju in diet induce obesity conditions.

• 出版日期2014-1