Association of Macroeconomic Factors With Nonrelapse Mortality After Allogeneic Hematopoietic Cell Transplantation for Adults With Acute Lymphoblastic Leukemia: An Analysis From the Acute Leukemia Working Party of the EBMT

作者：Giebel Sebastian^*; Labopin Myriam; Ibatici Adalberto; Browne Paul; Czerw Tomasz; Socie Gerard; Unal Ali; Kyrcz Krzemien Slawomira; Bacigalupo Andrea; Goker Hakan; Potter Mike; Furness Caroline L; McQuaker Grant; Beelen Dietrich; Milpied Noel; Campos Antonio; Craddock Charles; Nagler Arnon; Mohty Mohamad

来源：Oncologist, 2016, 21(3): 377-383.

DOI：10.1634/theoncologist.2015-0314

• Health care expenditure
• Human development index
• Hematopoietic cell transplantation
• Acute lymphoblastic leukemia
• Non-relapse mortality

Purpose. From a global perspective, the rates of allogeneic hematopoietic cell transplantation (alloHCT) are closely related to theeconomic status of acountry. However, a potential association with outcome has notyet been documented. The goal of this study was to evaluate effects of health care expenditure (HCE), Human Development Index (HDI), team density, and center experience on nonrelapse mortality (NRM) after HLA-matched sibling alloHCT for adults with acute lymphoblastic leukemia (ALL).
Patients and Methods. A total of 983 patients treated with myeloablative alloHCT between 2004 and 2008 in 24 European countries were included.
Results. In a univariate analysis, the probability of day 100 NRM was increased for countries with lower current HCE (8% vs. 3%; p = .06), countries with lower HDI (8% vs. 3%; p = .02), and centerswith less experience (8% vs. 5%; p = .04). In addition, the overall NRM was increased for countries with lower current HCE (21% vs. 17%; p = .09) and HDI (21% vs. 16%; p = .03) and for centerswith lower activity(21% vs. 16%; p = .07). In a multivariate analysis, the strongest predictive model for day 100 NRM included current HCE greater than the median (hazard ratio [HR], 0.39; p = .002). The overall NRM was mostly predicted by HDI greater than the median (HR, 0.65; p = .01). Both lower current HCE and HDI were associated with decreased probability of overall survival.
Conclusion. Both macroeconomic factors and the socioeconomic status of a country strongly influence NRM after alloHCT for adults with ALL. Our findings should be considered when clinical studies in the field of alloHCT are interpreted.

• 出版日期2016-3