Anti-tumor effect and influence of Gekko gecko Linnaeus on the immune system of sarcoma 180-bearing mice

作者：You Qi; Han Shiyu; Zhang Yuanlong; Zheng Jianhua^*

来源：Molecular Medicine Reports, 2009, 2(4): 573-577.

DOI：10.3892/mmr_00000139

• Gekko gecko Linnaeus
• traditional medicine
• anti-tumor
• immune

Gekko gecko Linnaeus (GgL) is an extract used in traditional Chinese medicine. In the present study, we examined the anti-tumor activity of GgL and its effect on the immune system of mice. Sarcoma 180-bearing mice were used as the animal model, and cisplatin was applied as the positive control drug. The mice were randomly divided into six groups, and each group was treated with a different drug or drug concentration. The effects of GgL were evaluated based on its anti-tumor activity and prolongation of the lifespan, the lymphocyte transformation rate and pathological changes observed in the tumors. The results suggest that GgL has antitumor activities and up-regulates the immune system in a dose-dependent manner. This study provides original data related to the anti-tumor and immune up-regulating function of GgL.

• 出版日期2009-8
• 单位哈尔滨医科大学