Acetylenic thiophenes from the roots of Echinops ellenbeckii from Ethiopia

作者：Hymete A; Rohloff J^*; Kjosen H; Iversen TH

来源：Natural Product Research, 2005, 19(8): 755-761.

DOI：10.1080/1478641042000301711

• E. ellenbeckii O. Hoffm
• Asteraceae
• acetylenic thiophenes
• fatty acids
• fatty acid
• esters
• GC-MS
• HRMS
• NMR

The hexane fraction from the roots of Echinops ellenbeckii O. Hoffm. from Ethiopia yielded seven acetylenic thiophenes of which five compounds (1, 3, 4, 6, 7) are reported for the first time in this species: the monothiophenes 5-(penta-1,3-diynyl)-2-(but-3-en-1-ynyl)-thiophene (1), 5-(penta1,3-diynyl)-2-(4-acetoxy-but-1-ynyl)-thiophene (2), 5-(penta-1,3-diynyl)-2-(3-hydroxy-4-acetoxybut-1-ynyl)-thiophene (3), 5-(penta-1,3-diynyl)-2-(3,4-diacetoxy-but-1-ynyl)-thiophene (4), 5-(penta-1,3-diynyl)-2-(3-chloro-4-acetoxy-but-1-ynyl)-thiophene (5), 5-(penta-1,3-diynyl)-2(3,4-epoxy-but-1-ynyl)-thiophene (6) and the dithiophene 5-[(5-acetoxymethyl-2-thienyl)-2(but-3-en-1-ynyl)]-thiophene (7). Additionally, four fatty acids (C-14, C-15, C-16 and C-18), seven fatty acid esters and three long-chain hydrocarbons could be identified. All the structures were elucidated on the basis of spectral data by GC-MS, HRMS and the NMR techniques.

• 出版日期2005-12