A census of RND superfamily proteins in the Burkholderia genus

作者：Perrin Elena; Fondi Marco; Papaleo Maria Cristiana; Maida Isabel; Emiliani Giovanni; Buroni Silvia; Pasca Maria Rosalia; Riccardi Giovanna; Fani Renato^*

来源：Future Microbiology, 2013, 8(7): 923-937.

DOI：10.2217/fmb.13.50

• antibiotic resistance
• Burkholderia
• efflux pumps
• genomics
• new antibiotics
• RND

Aim: The aim of this work was to analyze the eight resistance-nodulation-cell division (RND) families (a group of proteins mainly involved in multidrug resistance of Gram-negative bacteria) in 26 Burkholderia genomes in order to gain knowledge regarding their presence and distribution, to obtain a platform for future experimental tests aimed to identify new molecular targets to be used in antimicrobial therapy against Burkholderia species and to refine the annotation of RND-like sequences in these genomes. Materials %26 methods: A total of 417 coding sequences were retrieved and analyzed using different bioinformatics tools. Results %26 conclusion: A complex pattern of RND presence and distribution in the different Burkholderia species was disclosed and a core of proteins represented in all 26 genomes was identified. These core%26apos; proteins might represent useful targets of new synthetic antimicrobial compounds. Furthermore, the annotation of RND-like sequences in Burkholderia was refined.

• 出版日期2013-7