A Case Report of Improved Metabolic Control After Conversion From Everolimus to Cyclosporin A: Role of Adipose Tissue Mechanisms?

作者:Pereira M J; Eriksson J W; Svensson M K*
来源:Transplantation Proceedings, 2014, 46(7): 2377-2380.
DOI:10.1016/j.transproceed.2014.02.018

摘要

Background. New-onset diabetes after transplantation is associated with an increase in risk of graft failure, cardiovascular disease, and mortality. Therefore, it compromises the overall beneficial outcome of organ transplantation. Case Report. A patient with new-onset diabetes after renal transplantation showed glucose and lipid metabolism improvements after switching immunosuppressant from everolimus to cyclosporin A. A subcutaneous adipose tissue biopsy displayed changes in gene and protein expression that could contribute to the clinical improvement of hyperglycemia and dyslipidemia.

  • 出版日期2014-9