Histopathological evaluation and immunohistochemical study of estrogen receptor alpha, HER-2 and Ki-67 in canine neoplastic mammary lesions

作者：Kurilj Andrea Gudan^*; Hohsteter Marko; Artukovic Branka; Severin Kresimir; Sostaric Zuckermann Ivan Conrado; Beck Ana; Seiwerth Sven; Sabocanec Ruza; Grabarevic Zeljko

来源：Veterinarski Arhiv, 2011, 81(6): 709-722.

• mammary tumors
• dog
• ER alpha
• HER-2
• Ki-67

The frequency of different types of mammary lesions and their relationship with histologic grade was investigated. One hundred and forty-six mammary lesions were classified according to the World Health Organization (WHO) criteria. Selected lesions (51 malignant and 24 benign) were investigated to determine the immunohistochemical expression of estrogen receptor alpha (ER alpha), HER-2 and Ki-67 and their relationship with tumor factors. The most common breeds affected were cross breeds, poodles, cocker spaniels and German shepherds and the median age of tumor diagnosis was 10 years (range 4 - 15 years of age). Classification of all canine mammary gland lesions revealed 110 (75.3%) malignant and 36 (24.7%) benign tumors. ER alpha was expressed by 9/24 (37.5%) benign and 9/51 (17.6%) malignant tumors. HER-2 protein was detected in 5/51 (9.8%) malignant tumors but none in the 24 benign tumors. The Ki-67 index was higher in malignant (mean 29.5) than benign (mean 9.1) tumors (P<0.001) and significantly higher in anaplastic carcinomas than tubulopapillary carcinomas (P<0.05).

• 出版日期2011-12