Novel approaches to screening guanidine derivatives

作者：Rauf Muhammad Khawar; Imtiaz ud Din; Badshah Amin^*

来源：Expert Opinion on Drug Discovery, 2014, 9(1): 39-53.

DOI：10.1517/17460441.2013.857308

• anti-protozoal
• guanidine alkaloids
• guanidines
• marine sponge
• thymidyl deoxyribonucleic guanidine dinucleotide

Introduction: Compounds containing guanidine moiety, originating both from natural and synthetic sources, have found potential applications in both synthetic and medicinal chemistry. Indeed, guanidine functionality can be found in many natural and pharmaceutical products as well as in cosmetic ingredients produced by synthetic methods.
Areas covered: This review covers the latest developments in the research undertaken for the therapeutic application of newly synthesized guanidine derivatives including: small peptides and peptidomimetics. This article encompasses the selected literature published in the last three decades with a focus on the novel approaches for screening of lead drug candidates with their pharmacological action.
Expert opinion: Guanidines, as they are both organically based and also hydrophilic in nature, have undergone a mammoth amount of screening and testing to discover promising lead structures with a CN3 core, appropriate for potential future drug development. The compounds have the potential to be neurodegenerative therapeutic options, as well as: anti-inflammatory, anti-protozoal, anti-HIV, chemotherapeutic, anti-diabetic agents and so on. It is true that guanidine-based compounds of natural sources also, like synthetic and virtually designed drugs, have been of significant interest and have the potential to be useful therapeutic options in the future. As for now, however, there is not sufficient data to support their use in a number of the suggested areas, and further studies are required.

• 出版日期2014-1