Novel antiviral activity of dialdehyde starch

作者：Song Le; Cruz Caroline; Farrah Samuel R; Baney Ronald H^*

来源：Electronic Journal of Biotechnology, 2009, 12(2): 6.

DOI：10.2225/vol12-issue2-fulltext-6

• antiviral
• biocide
• dialdehyde starch
• virus

A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.

• 出版日期2009-4-15