Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants

作者：Beima-Sofie Kristin; Wamalwa Dalton; Maleche-Obimbo Elizabeth; Lingappa Jairam R.; Mackelprang Romel; Gantt Soren; John-Stewart Grace; Casper Corey; Slyker Jennifer A.^*

来源：AIDS, 2018, 32(2): 267-270.

DOI：10.1097/QAD.0000000000001680

Polymorphisms in the Toll-like receptor 9 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having one or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42 vs. 11%, P=0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (hazard ratio=4.2, P=0.02) compared with 1635GG. In addition, 1635A was associated with 0.4log(10) copies/ml lower median EBV levels in HIV-infected infants (P=0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.

• 出版日期2018-1-14