Association between functional variants in BIRC5/survivin gene 3 ' untranslated region and mRNA expression in lymphoblastoid cell lines

作者：Pu Feifei; Shao Zengwu^*; Yang Shuhua; Liu Jianxiang; Lin Song; Ma Xiucai; Yang Haofei

来源：Oncology Letters, 2015, 10(4): 2319-2322.

DOI：10.3892/ol.2015.3507

• genetic
• microRNA
• polymorphisms
• baculoviral inhibitor of apoptosis repeat-containing 5
• survivin
• variant

Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5)/survivin genetic microRNA (miRNA) binding site variants in the 3' untranslated region (3'UTR) are known to be significantly associated with cancer risk. However, the roles of genetic variants in BIRC5/survivin gene 3'UTRs and post-transcriptional regulation have not been elucidated. In the present study, we revealed that rs1042489, rs1042542, rs17882360, rs2239680, rs2661694 and rs4789560 in the BIRC5/survivin 3'UTR have potential miRNA binding sites using bioinformatics analysis. However, only rs1042489 was significantly associated with BIRC5/survivin mRNA expression in lymphoblastoid cell lines (P=0.030); rs1042489 may be a putative variant mediating the post-transcriptional regulation of the target BIRC5/survivin gene. An in-depth understanding of how 3'UTR variants regulate BIRC5/survivin activity is expected to pave the way to targeting the BIRC5/survivin pathway in cancer therapy.

• 出版日期2015-10
• 单位华中科技大学