A new synthesis of pyrrolo[3,2-d]pyrimidine derivatives by a one-pot, three-component reaction in the presence of L-proline as an organocatalyst

作者：Javahershenas Ramin; Khalafy Jabbar

来源：Heterocyclic Communications, 2018, 24(1): 37-41.

DOI：10.1515/hc-2017-0187

• 1,3-Dimethyl-6-aminouracil
• 4-hydroxycoumarin
• 6-aminouracil
• arylglyoxals
• one-pot
• pyrrolo[3,2-d]pyrimidines

A one-pot, three-component reaction of 4-hydroxycoumarin, arylglyoxals, and 6-aminouracil or 1,3-dimethyl-6-aminouracil in the presence of L-proline as an organocatalyst in acetic acid under reflux conditions provided a series of new pyrrolo[3,2-d]pyrimidine derivatives in good yields.

• 出版日期2018-2