Nature-derived microbiota exposure as a novel immunomodulatory approach

作者：Nurminen Noora; Lin Jake; Gronroos Mira; Puhakka Riikka; Kramna Lenka; Vari Heli K; Viskari Hanna; Oikarinen Sami; Roslund Marja; Parajuli Anirudra; Tyni Iiris; Cinek Ondrej; Laitinen Olli^*; Hyoty Heikki^*; Sinkkonen Aki^*

来源：Future Microbiology, 2018, 13(7): 737-744.

DOI：10.2217/fmb-2017-0286

• 16s rRNA
• biodiversity hypothesis
• immune-mediated diseases
• immune modulation
• microbial diversity
• microbiome

Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

• 出版日期2018-6