alpha-Pyrones from the marine-derived actinomycete Nocardiopsis dassonvillei subsp dassonvillei XG-8-1

作者：Fu, Peng^*; Liu, Peipei; Gong, Qianhong; Wang, Yi; Wang, Pei; Zhu, Weiming

来源：RSC Advances, 2013, 3(43): 20726-20731.

DOI：10.1039/c3ra43656j

• DIKETOPIPERAZINE DERIVATIVES
• ABSOLUTE-CONFIGURATIONS
• NATURAL-PRODUCTS
• GROWTH
• STRAIN
• INDOLOCARBAZOLES
• FUSALANIPYRONE
• PNU-140690
• PIRONETIN
• ASSAY

Seven new alpha-pyrones, nocapyrones H-N (1-7) were isolated from the marine-derived actinomycete strain, Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1. The new structures 1-7 were determined by spectroscopic analysis, CD spectra, ECD quantum chemical calculations and the modified Mosher's method. Compounds 1, 2 and 6 showed inhibitory effects on quorum sensing (QS) controlled gene expression in Chromobacterium violaceum CV026 and Pseudomonas aeruginosa QSIS-lasl biosensors at a concentration of 100 mu g mL(-1), respectively. This is the first report of inhibition of alpha-pyrones on QS controlled gene expression in pathogenic bacteria.

• 出版日期2013
• 单位中国海洋大学