Beyond the Discovery Void: New targets for antibacterial compounds

作者:Broughton Claire E; Van den Berg Hugo A*; Wemyss Alan M; Roper David I; Rodger Alison
来源:Science Progress: A Review Journal of Current Scientific Advance , 2016, 99(2): 153-182.
DOI:10.3184/003685016X14616130512308

摘要

Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the "discovery void." We discuss the traditional molecular targets of antibiotics as well as putative novel targets.

  • 出版日期2016-6