Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats

作者：Kumar Parveen^*; Prashanth Krishna Shastrula; Gaikwad Anil Bhanudas; Vij Mohit; Barua Chandana C; Bezbaruah Babul

来源：Environmental Toxicology and Pharmacology, 2013, 36(3): 883-890.

DOI：10.1016/j.etap.2013.08.004

• Cisplatin
• Inflammation
• Nephrotoxicity
• Rosiglitazone
• Pretreatment
• Posttreatment

Cisplatin is one of the most common chemotherapeutic drugs used against various solid, tumours. Despite of its therapeutic benefits, its use in clinical practice is often limited because of dose, related toxicity. The nephrotoxic potential of cisplatin has been ascribed to its accumulation in the, renal tubular cells generating reactive oxygen species (ROS), activation of Bax, increased secretion of, TNF alpha and activation of certain inflammatory mediators like cytokines. The present investigation was, undertaken with an objective to study the effect of rosiglitazone against cisplatin induced, nephrotoxicity. Pretreatment of rosiglitazone prevents cisplatin induced nephrotoxicity which was, clearly evident from the renal biochemical parameters like reduced BUN, creatinine and TNF alpha levels, and increased albumin levels, which was also supported by histopathological studies of the kidneys. In contrast, posttreatment of rosiglitazone was not able to protect the renal damage in cisplatin induced, renal toxicity. These results showed the variation of pre & posttreatment effects of rosiglitazone, against the cisplatin induced nephrotoxicity.

• 出版日期2013-11