Toll-like receptors in hepatitis C infection: Implications for pathogenesis and treatment

作者：Howell Jessica^*; Angus Peter; Gow Paul; Visvanathan Kumar

来源：Journal of Gastroenterology and Hepatology, 2013, 28(5): 766-776.

DOI：10.1111/jgh.12170

• cell and molecular biology
• liver immunobiology
• viral hepatitis

Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.

• 出版日期2013-5