Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis

作者：Kitade Takashi; Horiki Noriyuki^*; Katsurahara Masaki; Totoki Toshiaki; Harada Tetsuro; Tano Shunsuke; Yamada Reiko; Hamada Yasuhiko; Inoue Hiroyuki; Tanaka Kyosuke; Gabazza Esteban C; Hayashi Hiroyuki; Tanaka Masanori; Takei Yoshiyuki

来源：Internal Medicine, 2015, 54(11): 1343-1347.

DOI：10.2169/internalmedicine.54.3690

• familial Mediterranean fever
• capsule endoscopy
• double balloon endoscopy
• endoscopy
• neutrophil infiltration
• infliximab

A 66-year-old Japanese man consulted our institution due to paroxysmal and repetitive bouts of fever and abdominal pain that had persisted for more than one week. Capsule and double-balloon endoscopy (DBE) showed petal-shaped mucosal redness with white hemming in the jejunum and ileum, and histopathology of the biopsy specimens revealed villous atrophy and cryptitis with extensive severe neutrophil infiltration. A genetic examination disclosed compound heterozygous MEFV mutations (E84K, P369S), and familial Mediterranean fever was diagnosed. Treatment with colchicine and infliximab was very effective in inducing the complete disappearance of symptoms and normalization of the endoscopic findings. To the best of our knowledge, this is the first report to describe the findings of small intestinal endoscopic images obtained using capsule and DBE.

• 出版日期2015