Assessment of Solubility and Intestinal Absorption In Vitro of Praziquantel in Solid Dispersions of Polyethylene Glycol 6000

作者：Correa Eliane M; Vila Marta M D C; Junior Jose M O; Zaparoli Roney E; Granato Marcia M; Goes Arielly L; Moraes Larissa C; Paula Fabio C; Chaud Marco V^*

来源：Latin American Journal of Pharmacy, 2011, 30(10): 1910-1915.

• 9Intestinal absorption
• Polyethilene glicol 6000
• Praziquantel solubility
• Solid dispersion

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assessed in purified water and TC-199 buffer. The everted intestinal sac model was employed to assess, in vitro, intestinal absorption of PZQ. A significant enhancement in both in vitro solubility and intestinal absorption of PZQ was found in solid dispersions compared to pure PZQ and physical mixtures. This positive series of preliminary results showed that solid dispersion of PEG 6000 is a valuable strategy for increasing bioavallability of PZQ and could also prove useful for other poorly water-soluble drugs.

• 出版日期2011-12