Photodynamic Therapy in Non-Gastrointestinal Thoracic Malignancies

作者：Kidane Biniam; Hirpara Dhruvin; Yasufuku Kazuhiro^*

来源：International Journal of Molecular Sciences, 2016, 17(1): 135.

DOI：10.3390/ijms17010135

• photodynamic therapy
• non-small cell lung cancer
• thoracic malignancy
• mesothelioma
• bronchial obstruction
• airway obstruction
• pleural metastasis

Photodynamic therapy has a role in the management of early and late thoracic malignancies. It can be used to facilitate minimally-invasive treatment of early endobronchial tumours and also to palliate obstructive and bleeding effects of advanced endobronchial tumours. Photodynamic therapy has been used as a means of downsizing tumours to allow for resection, as well as reducing the extent of resection necessary. It has also been used successfully for minimally-invasive management of local recurrences, which is especially valuable for patients who are not eligible for radiation therapy. Photodynamic therapy has also shown promising results in mesothelioma and pleural-based metastatic disease. As new generation photosensitizers are being developed and tested and methodological issues continue to be addressed, the role of photodynamic therapy in thoracic malignancies continues to evolve.

• 出版日期2016-1