Association of Abdominal Aortic Wall Thickness in the Newborn with Maternal Factors

作者：Iwashima Satoru^*; Ishikawa Takamichi; Akira Ohishi; Itou Hiroaki

来源：American Journal of Perinatology, 2012, 29(6): 441-448.

DOI：10.1055/s-0032-1304825

• cardiovascular risk
• intima-media thickness
• newborn
• maternal factors

Purpose The goal of the present study is to carry out prospective echocardiographic measurements of intima-media thickness (IMT) in the abdominal artery of newborns. %26lt;br%26gt;Methods Study subjects were 96 mothers and their newborns. We measured the adjusted IMT (aIMT, mm/mm) of newborn abdominal arteries by high-resolution ultrasound and evaluated the association of aIMT with various maternal and newborn factors. %26lt;br%26gt;Results Negative correlations were observed between aIMT and gestational age (r = -0.678, p %26lt; 0.01) and positive correlations between aIMT and placenta-to-fetus weight ratio (r = 0.418, p %26lt; 0.01). Comparing the small-for-gestational-age (SGA) versus appropriate-for-gestational-age (AGA) categories, aIMT in the SGA (n = 14) was greater than in the AGA (n = 82), with values of [0.115 (0.117) mm/mm versus 0.084 (0.074) mm/mm, p %26lt; 0.01], respectively. A multiple linear regression analysis was performed with aIMT as a dependent variable, and significant correlations were noted with gestational age (R-2 = 0.524, beta = -0.515, p %26lt; 0.001 for gestational age). %26lt;br%26gt;Conclusion On the basis of these findings, we suggest that aIMT thickness is associated with placenta-to-fetus weight ratio and gestational age, and that increased values of aIMT in SGA may indicate presence of a latent link to cardiovascular disease that might otherwise go undetected in infancy.

• 出版日期2012-6