Absence of leptin triggers type 1 diabetes

作者：Mittendorfer Bettina^*; Klein Samuel

来源：Nature Medicine, 2014, 20(7): 705-706.

DOI：10.1038/nm.3629

Leptin deficiency, which is associated with type 1. diabetes, is a critical factor in the pathophysiology of this disease, a new study in rats shows. The lack of this hormone triggers a cascade of neuroendocrine events that affect adipose tissue and the liver, resulting in hyperglycemia and ketoacidosis (pages 759-763).

• 出版日期2014-7