Flexible and Highly Biocompatible Nanofiber-Based Electrodes for Neural Surface Interfacing

作者：Heo Dong Nyoung; Kim Han Jun; Lee Yi Jae; Heo Min; Lee Sang Jin; Lee Donghyun; Do Sun Hee; Lee Soo Hyun; Kwon Il Keun

来源：ACS Nano, 2017, 11(3): 2961-2971.

DOI：10.1021/acsnano.6b08390

• nerve electrode
• flexible device
• neural interfacing
• electrospun nanofiber
• inkjet printing

Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device appliCations for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications.

• 出版日期2017-3