An efficient method for the synthesis of N-amino-2-pyridones using reusable catalyst ZnO nanoparticles

作者：Safaei Ghomi Javad^*; Saberi Moghadam Mohammad Reza; Shahbazi Alavi Hossein; Asgari Kheirabadi Mehrnoosh

来源：Journal of Chemical Research, 2014, 38(10): 583-585.

DOI：10.3184/174751914X14109743944636

• N-amino-2-pyridones
• ZnO nanoparticles
• one-pot
• four-component reactions
• 1,6-diamino-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile

A concise and highly efficient protocol for the synthesis of N-amino-2-pyridones has been developed by a four-component coupling of hydrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes in the presence of ZnO nanoparticles under mild conditions. The key advantages of this process are using an inexpensive and reusable catalyst, easy work-up and excellent yields.

• 出版日期2014-10