Bilateral loss of cortical SEPs predict severe MRI lesions in neonatal hypoxic ischemic encephalopathy treated with hypothermia

作者：Suppiej Agnese; Cappellari Ambra; Talenti Giacomo; Cainelli Elisa; Di Capua Matteo; Janes Augusta; Longo Daniela; Mardari Rodica; Marinaccio Cristina; Pro Stefano; Sciortino Paola; Trevisanuto Daniele; Vittorini Roberta; Manara Renzo

来源：Clinical Neurophysiology, 2018, 129(1): 95-100.

DOI：10.1016/j.clinph.2017.10.020

• Perinatal asphyxia
• Cooled infants
• Evoked potentials
• Neonatal encephalopathy

Objective: The introduction of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy calls for reevaluation of the prognostic role of somatosensory evoked potentials (SEPs).
Methods: Among 80 consecutive neonates undergoing hypothermia for hypoxic-ischemic encephalopathy, 58 performed SEPs and MRI at 4-14 days of life and were recruited in this multicenter study. SEPs were scored as: 0 (bilaterally/unilaterally recorded N20) or 1 (bilaterally absent N20). The severity of brain injury was scored using MRI.
Results: Bilaterally absent N20 was observed in 10/58 neonates (17%); all had moderate/severe MRI abnormalities; 36/48 neonates (75%) with score 0 at SEPs had normal MRI. The positive predictive value of SEPs on MRI outcome was of 1.00, while the negative predictive value 0.72, sensitivity 0.48, specificity 1.00, with an accuracy of 0.78 (p < .001).
Conclusions: Bilateral absence of cortical SEPs predicts moderate/severe MRI pattern of injury.

• 出版日期2018-1