Detection of Gram-Negative beta-Lactamase Producing Pathogens in the Clinical Lab

作者：Thomson Kenneth S^*

来源：Current Pharmaceutical Design, 2013, 19(2): 250-256.

• beta-lactamase
• ESBL
• CTX-M
• AmpC
• carbapenemase
• KPC
• metallo-beta-lactamase

Pathogens that produce extended spectrum beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases, and carbapenemases may appear falsely susceptible to beta-lactam antibiotics in the laboratory. Infected patients may be treated with inappropriate antibiotics if laboratories do not perform accurate tests to detect these resistance mechanisms. Furthermore the resistant pathogens may spread undetected to amplify the therapeutic and infection control challenge. This review makes a case for why and how laboratories should perform tests to detect beta-lactamase-mediated resistance in gram-negative pathogens.

• 出版日期2013-1