科研之友
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摘要
The synthesis of a new, highly efficient cis-ion-tagged catalyst (8a), possessing an amide linkage between the imidazolium tag and the proline ring, is described. This new bench-stable catalyst has been tested in the classic asymmetric aldol condensation between ketones and aldehydes "in the presence" of water, and is proposed as a valuable alternative to the analogous but more sensitive ester cis-2d. Catalyst 8a displayed an excellent efficiency in terms of catalyst loading and stereochemical control.
- 出版日期2011-12
