Altered neurophysiologic response to intermittent theta burst stimulation in Tourette syndrome

作者：Wu Steve W^*; Gilbert Donald L

来源：Brain Stimulation, 2012, 5(3): 315-319.

DOI：10.1016/j.brs.2011.04.001

• Tourette syndrome
• neurophysiology
• neuroplasticity
• transcranial magnetic stimulation
• theta burst stimulation

Background
The motor system in Tourette syndrome has been found to be abnormal in previous fine-motor and neurophysiologic studies.
Objective
This novel pilot study uses repetitive transcranial magnetic stimulation as a method to characterize the neurophysiology of the motor system in Tourette syndrome.
Method
We investigated the modulation of cortical excitability in adult Tourette syndrome patients by measuring motor-evoked potential amplitudes before and after applying intermittent theta burst transcranial magnetic stimulation.
Results
Motor-evoked potential amplitude changes over I and 10 minutes after intermittent theta burst transcranial magnetic stimulation were greater in 11 healthy controls than 10 adult patients with Tourette syndrome (P = 0.004).
Conclusions
This altered neurophysiologic response to intermittent theta burst stimulation may contribute to the understanding of motor cortical mechanisms in Tourette syndrome.

• 出版日期2012-7