Allogeneic cell transplant expands bone marrow distribution by colonizing previously abandoned areas: an FDG PET/CT analysis

作者：Fiz Francesco; Marini Cecilia; Campi Cristina; Massone Anna Maria; Podesta Marina; Bottoni Gianluca; Piva Roberta; Bongioanni Francesca; Bacigalupo Andrea; Piana Michele; Sambuceti Gianmario; Frassoni Francesco^*

来源：Blood, 2015, 125(26): 4095-4102.

DOI：10.1182/blood-2015-01-618215

Mechanisms of hematopoietic reconstitution after bone marrow (BM) transplantation remain largely unknown. We applied a computational quantification software application to hybrid 18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) images to assess activity and distribution of the hematopoietic system throughout the whole skeleton of recently transplanted patients. Thirty-four patients underwent PET/CT 30 days after either adult stem cell transplantation (allogeneic cell transplantation [ACT]; n = 18) or cord blood transplantation (CBT; n = 16). Our software automatically recognized compact bone volume and trabecular bone volume (IBV) in CT slices. Within IBV, coregistered PET data were extracted to identify the active BM (ABM) from the inactive tissue. Patients were compared with 34 matched controls chosen among a published normalcy database. Whole body ABM increased in ACT and CBT when compared with controls (12.4 +/- 3 and 12.8 +/- 6.8 vs 8.1 +/- 2.6 mL/kg of ideal body weight [IBW], P < .001). In long bones, ABM increased three-and sixfold in CBT and ACT, respectively, compared with controls (0.9 +/- 0.9 and 1.7 +/- 2.5 vs 0.3 +/- 0.3 mL/kg IBW, P < .01). These data document an unexpected distribution of transplanted BM into previously abandoned BM sites.

• 出版日期2015-6-25