A New Taxane from the Hard Wood of Taxus cuspidata

作者:Yu Shu Hong; Zhang Man li; Wang Yu Fang; Huo Chang Hong; Gu Yu Cheng; Shi Qin Wen*
来源:Zeitschrift fur Naturforschung Section B-A Journal of Chemical Sciences, 2010, 65(5): 635-638.

摘要

A new taxoid metabolite with an unusual double bond between C-13 and C-14 was isolated from the methanol extract of the hard wood of Taxus euspidata. The structure was established as 2 alpha,5 alpha,7 beta,9 alpha,10 beta,13 beta-hexaacetoxy-11 beta-hydroxyl-19 beta-benzoxytaxa-4(20),13-dien-12,16-epoxide (1), named 5,13-diacetyltaxinine M-13-enol, on the basis of spectral analysis including (1)H NMR. (13)C NMR, HMQC, HMBC, NOESY and confirmed by HR-FAB-MS.