Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats

作者：Ahmed Romana; Tanvir E M; Hossen Md Sakib; Afroz Rizwana; Ahmmed Istiyak; Rumpa Nur E Noushin; Paul Sudip; Gan Siew Hua^*; Sulaiman Siti Amrah; Khalil Md Ibrahim^*

来源：Evidence-Based Complementary and Alternative Medicine, 2017, 2017: 5370545.

DOI：10.1155/2017/5370545

Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values. Herein, we report the antioxidant properties and cardioprotective properties of MP in isoproterenol-(ISO-) inducedmyocardial infarction in rats. MaleWistar rats (n = 32) were pretreated orally with an ethanol extract of MP (100 mg/kg/day) for 30 consecutive days. Subcutaneous injection of ISO(85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes and cardiac troponin I levels and altered serum lipid profiles. In addition significantly increased lipid peroxides and decreased activities of cellular antioxidant defense enzymes were observed in the myocardium. However, pretreatment of ischemic rats with MP ameliorated the biochemical parameters, indicating the protective effect of MP against ISO-induced ischemia in rats. Histopathological findings obtained for the myocardium further confirmed the biochemical findings. It is concluded that MP exhibits cardioprotective activity against ISO-induced oxidative stress through its direct cytotoxic radical-scavenging activities. It is also plausible that MP contributed to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.

• 出版日期2017