Antibacterial Activity of Alanine-Derived Gemini Quaternary Ammonium Compounds

作者：Piecuch Agata; Oblak Ewa^*; Guz Regner Katarzyna

来源：Journal of Surfactants and Detergents, 2016, 19(2): 275-282.

DOI：10.1007/s11743-015-1778-3

• Gemini quaternary ammonium compounds
• Biofilm
• Adhesion
• Pseudomonas aeruginosa
• Staphylococcus epidermidis

The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms of Pseudomonas aeruginosa and Staphylococcus epidermidis, and were lethal to adherent cells of S. epidermidis. Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL-12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry.

• 出版日期2016-3