Adaptive optimal designs for dose-finding studies based on sigmoid E-max models

作者：Wang Tianhua; Yang Min^*

来源：Journal of Statistical Planning and Inference, 2014, 144: 188-197.

DOI：10.1016/j.jspi.2013.09.003

• Dose-finding
• Adaptive designs
• Loewner order
• Optimal designs

The adaptive design strategy is a feasible approach for optimal designs in dose-finding studies, where the information matrices usually depend on the unknown parameters. Focusing on three pharmacodynamics sigmoid E-max models, we derive the corresponding simple formats of the adaptive optimal designs regardless of the optimality criteria or parameters of interest. An algorithm for deriving a specific adaptive optimal design is developed. A simulation study comparing the adaptive optimal designs and the uniform designs is also performed.

• 出版日期2014-1