High-resolution HLA A similar to B similar to DRB1 haplotype frequencies from the Ezer Mizion Bone Marrow Donor Registry in Israel

作者：Manor Sigal^*; Halagan Michael; Shriki Nira; Yaniv Isaac; Zisser Bracha; Maiers Martin; Madbouly Abeer; Stein Jerry

来源：Human Immunology, 2016, 77(12): 1114-1119.

DOI：10.1016/j.humimm.2016.09.004

• HLA
• Haplotype and allele frequencies
• Jewish population
• Bone marrow donor registry

We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A,-B and -DRB1 loci using HLA genotyping methods. HLA A similar to B similar to DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion.

• 出版日期2016-12