An Efficient Two-Step Synthesis of N-Substituted Thioureas in Functional Ionic Liquid

作者：Zhao Huarong^*; Wang Haiyan; Lu Fengping

来源：Acta Chimica Sinica, 2011, 69(19): 2293-2298.

• acyl chloride
• amine
• functional ionic liquid
• N-substituted thiourea

N-Substituted thioureas were synthesized efficiently by two-step reaction: (1) acyl chlorides and primary amides reacted together in functional [emim]SCN rapidly at room temperature to form N-benzoyl-N'-alkylthioureas in high yields. [emim]SCN acted both as an initial material and reaction solvent. (2) N-benzoyl-N'-alkylthioureas were hydrolyzed in NaOH/H2O/EtOH to yield N-substituted thioureas with almost 100% yield. A new efficient and green synthesis of N-substituted thioureas showing good practicality was provided.

• 出版日期2011-10-14
• 单位浙江大学