A cross-metathesis approach to the synthesis of new etretinate type retinoids, ethyl retinoate and its 9Z-isomer

作者：Maj Jadwiga; Morzycki Jacek W; Rarova Lucie; Wasilewski Grzegorz; Wojtkielewicz Agnieszka^*

来源：Tetrahedron Letters, 2012, 53(40): 5430-5433.

DOI：10.1016/j.tetlet.2012.07.122

• Cross-metathesis
• Retinoids
• Etretinate analogues
• Polyenes

Two aromatic retinoids were synthesized from styrene derivatives using a novel strategy with a cross-metathesis reaction as a key step. The biological activity of the new etretinate analogues was tested. Cross-metathesis reactions were also employed for the preparation of ethyl retinoate and its 9Z-isomer via the C-15 + C-5 route.

• 出版日期2012-10-3