Central nervous system infection caused by vancomycin-intermediate Staphylococcus aureus (SCCmec type IV, ST8)

作者：Kino Hiroyoshi; Suzuki Hiromichi^*; Yamaguchi Tetsuo; Notake Shigeyuki; Oishi Tsuyoshi; Ito Yoshiro; Nakamura Kazuhiro; Miyazaki Haruko; Matsumoto Tetsuya; Uemura Kazuya; Matsumura Akira

来源：Journal of Infection and Chemotherapy, 2014, 20(9-10): 643-646.

DOI：10.1016/j.jiac.2014.06.008

• Vancomycin-intermediate Staphylococcus aureus
• Brain abscess
• Subdural abscess

A 77-year-old Japanese man with a history of surgical treatment of chronic subdural hemorrhage was hospitalized for drainage of a subdural abscess and brain abscess in the right occipital area. Pus obtained from both the subdural abscess and brain abscess grew vancomycin-intermediate Staphylococcus aureus (VISA) (minimum inhibitory concentration = 4 mu g/mL), which was confirmed by population analysis. The SCCmec type and sequence type were subsequently identified as IV and ST8, respectively. The VISA strains were both sensitive to levofloxacin, clindamycin, minocycline, and linezolid. The patient was successfully treated with linezolid and discharged on day 51 after admission. We herein describe the first reported case of a brain abscess and subdural abscess caused by VISA in Japan.

• 出版日期2014-10