Membranous nephropathy with Neuromyelitis optica spectrum disorder

作者：Li, Xiangling; Wang, YanQiang^*

来源：Multiple Sclerosis and Related Disorders, 2017, 15: 49-51.

DOI：10.1016/j.msard.2017.05.007

• Membranous nephropathy
• Neuromyelitis optica spectrum disorders
• Proteinuria
• Intractable hiccup and vomiting

Membranous nephropathy (MN) accompanying Neuromyelitis optica spectrum disorders (NMOSD) has rarely been described previously. We recently presented a 45-year-old Chinese male presenting with recurrent lower extremity pitting edema, or eyelid edema, proteinuria and hyperlipidemia. especially intractable hiccup and vomiting, painful tonic spasm (PTS) as the revealing symptom of a demyelinating disorder of central nervous system. The kindey biopsy specimen showed MN stage 2. Serological testing revealed antibodies AQP4, MRI head and spine revealed medulla oblongata and C1-C2 cervical vertebra lesions. Treatment with methylprednisolone, cyclophosphamide, azathioprine resulted in consistent clinical improvement.

• 出版日期2017-7
• 单位潍坊医学院