A simple and efficient route for the synthesis of novel isoxazolyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones

作者：Eligeti Rajanarendar^*; Saini Rama Krishna; Samala Raju

来源：Journal of the Iranian Chemical Society, 2013, 10(4): 653-658.

DOI：10.1007/s13738-012-0197-x

• Intramolecular ipso-cyclization
• Carbimmonium ion
• 3-(3-Methyl-4-nitro-5-isoxazolyl)-1-aryl-2-azaspiro[4.5]deca-1,6,9-trien -8-ones

A new, simple and efficient method for the synthesis of novel isoxazolyl-2-azaspiro[4.5]deca-1,6,9-trien-8-ones is described by the intramolecular ipso-cyclization of 5-[(E)-2-(4-methoxyphenyl)-1-ethenyl]-3-methyl-4-nitroisoxazole with nitriles. In presence of 5-[(E)-2-(4-methoxyphenyl)-1-ethenyl]-3-methyl-4-nitroisoxazole, a variety of nitriles underwent the intramolecular ipso-cyclization smoothly, affording title compounds in moderate to good yields.

• 出版日期2013-8