Aged citrus peel (chenpi) extract reduces lipogenesis in differentiating 3T3-L1 adipocytes

作者：Guo, Jingjing; Cao, Yong; Ho, Chi-Tang; Jin, Shengkan^*; Huang, Qingrong^*

来源：Journal of Functional Foods, 2017, 34: 297-303.

DOI：10.1016/j.jff.2017.04.042

• Adipogenesis
• AMPK
• Chenpi
• 5-Demethylated polymethoxyflavones
• Lipogenesis
• Obesity

Aged citrus peel (chenpi) is made from the dry peel of the fruit of Citrus reticulate Blanco after aging process. It has long been used as a food ingredient, a dietary supplement, and for medicinal purpose. Compared to fresh citrus peel extract, chenpi extract contains more 5-demethylated polymethoxyflavones (5-OH PMFs). To investigate a potential direct role of chenpi extract on adipose tissue, we examined the effect of chenpi extract on differentiating 3T3-L1 cells. We showed that two types of chenpi extract varying in 5-OH PMF contents consistently reduces intracellular lipid accumulation without significantly affecting cell viability and proliferation. The reduction in lipid accumulation is correlated with AMP activated protein kinase (AMPK) activation and down-regulation of adipogenic transcription factors as well as lipogenic genes. The results indicate that chenpi extract may directly affect lipogenesis in adipose tissue and the content of 5-OH PMFs likely affects the anti-lipogenic activity of chenpi extract.

• 出版日期2017-7
• 单位rutgers; 华南农业大学