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摘要
The present work deals with the synthesis and characterization of four 1,4-dihydropyridine derivatives. These compounds were synthesized via a one-pot multicomponent condensation reaction with various aromatic aldehydes and evaluated for anticancer activity against three human hepatoma tumor cell lines (SMMC-7721, BEL-7405 and HCCLM3) and WI 38 as normal fibroblast cells were also used in this study. The results indicated that compound 4 showed the best result, with the highest inhibitory effects towards the three tested tumor cell lines, which were higher than that of the reference fluorouracil and the compound was non-cytotoxic to normal cells (IC50 values > 100 mu g/mL).
- 出版日期2016
- 单位兰州大学
