NT-proB natriuretic peptide, risk factors and asymptomatic left ventricular dysfunction: Results of the SCReening Evaluation of the Evolution of New Heart Failure Study (SCREEN-HF)

作者：McGrady Michele^*; Reid Christopher M; Shiel Louise; Wolfe Rory; Boffa Umberto; Liew Danny; Campbell Duncan J; Prior David; Stewart Simon; Krum Henry

来源：International Journal of Cardiology, 2013, 169(2): 133-138.

DOI：10.1016/j.ijcard.2013.08.089

• Asymptomatic left ventricular dysfunction
• Heart failure
• NT-proBNP
• Risk factors
• Epidemiology

Background: We assessed left ventricular dysfunction in a population at high risk for heart failure (HF), and explored associations between ventricular function, HF risk factors and NT-proB natriuretic peptide (NT-proBNP). %26lt;br%26gt;Methods and results: 3550 subjects at high risk for incident HF (= 60 years plus = 1 HF risk factor), but without pre-existing HF or left ventricular dysfunction, were recruited. Anthropomorphic data, medical history and blood for NT-proBNP were collected. Participants at highest risk (n = 664) (NT-proBNP highest quintile; N30.0 pmol/L) and a sample (n = 51) from the lowest NT-proBNP quintile underwent echocardiography. Participants in the highest NT-proBNP quintile, compared to the lowest, were older (74 years vs. 67 years; p %26lt; 0.001) and more likely to have coronary artery disease, stroke or renal impairment. In the top NT-proBNP quintile (n = 664), left ventricular systolic impairment was observed in 6.6% (95% CI: 4 to 8%) of participants and was associated with male gender, coronary artery disease, hypertension and NT-proBNP. At least moderate diastolic dysfunction was observed in 24% (95% CI 20 to 27%) of participants and was associated with diabetes and NT-proBNP. In this high risk population, NT-proBNPwas associatedwith left ventricular systolic impairment (p %26lt; 0.001) and moderate to severe diastolic dysp %26lt; 0.001) after adjustment for age, gender, coronary artery disease, diabetes, hypertension and obesity. %26lt;br%26gt;Conclusion: A high burden of ventricular dysfunctionwas observed in this high risk group. Combining NT-proBNP and HF risk factors may identify those with ventricular dysfunction. Thiswould allowresources to be focused on those at greatest risk of progression to overt HF.

• 出版日期2013-10-30