Nicotine and inflammatory neurological disorders

作者：Piao Wen Hua^*; Campagnolo Denise; Dayao Carlos; Lukas Ronald J; Wu Jie; Shi Fu Dong

来源：Acta Pharmacologica Sinica, 2009, 30(6): 715-722.

DOI：10.1038/aps.2009.67

• nicotine
• cigarette smoke
• immune system

Cigarette smoke is a major health risk factor which significantly increases the incidence of diseases including lung cancer and respiratory infections. However, there is increasing evidence that smokers have a lower incidence of some inflammatory and neurodegenerative diseases. Nicotine is the main immunosuppressive constituent of cigarette smoke, which inhibits both the innate and adaptive immune responses. Unlike cigarette smoke, nicotine is not yet considered to be a carcinogen and may, in fact, have therapeutic potential as a neuroprotective and anti-inflammatory agent. This review provides a synopsis summarizing the effects of nicotine on the immune system and its (nicotine) influences on various neurological diseases.

• 出版日期2009-6
• 单位宁夏回族自治区人民医院