An efficient and one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed via solid acid nano-catalyst

作者：Teimouri Abbas^*; Chermahini Alireza Najafi

来源：Journal of Molecular Catalysis A: Chemical , 2011, 346(1-2): 39-45.

DOI：10.1016/j.molcata.2011.06.007

• Clay
• Zeolite
• Sulfated zirconia
• Green synthesis
• 2,4,5-Trisubstituted imidazoles
• 1,2,4,5-Tetrasubstituted imidazoles

A simple highly versatile and efficient synthesis of 2,45-trisubstituted imidazoles is achieved by three component cyclocondensation of 1,2-dicarbonyl compounds, aldehydes and NH4OAc, as ammonia source using clays, zeolite, nano-crystalline sulfated zirconia (SZ) as catalyst in ethanol at moderate temperature. Moreover, the utility of this protocol was further explored conveniently for the one-pot, four component synthesis of 1,2,4,5-tetrasubstituted imidazoles in high yields, short reaction times and milder conditions, easy work-up and purification of products by non-chromatographic methods. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of their efficiency.

• 出版日期2011-7-20