A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

作者：Cuccioloni M^*; Bonfili L; Mozzicafreddo M; Cecarini V; Pettinari R; Condello F; Pettinari C; Marchetti F; Angeletti M; Eleuteri A M

来源：RSC Advances, 2016, 6(46): 39636-39641.

DOI：10.1039/c6ra06403e

A ruthenium(II) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.

• 出版日期2016