Nickel Catalysis Enables Hetero [2+2+1] Cycloaddition between Yne-Isothiocyanates and Isonitriles with Low Catalyst Loading

作者：Liu, Rui-Juan; Wang, Peng-Fei; Yuan, Wen-Kui; Wen, Li-Rong^*; Li, Ming^*

来源：Advanced Synthesis & Catalysis, 2017, 359(8): 1373-1378.

DOI：10.1002/adsc.201601271

• 2-alkynylaryl isothiocyanates
• hetero [2+2+1] cycloaddition
• isonitriles
• nickel catalyst

Nickel(II) can be used to catalyze the hetero [2+2+1] cycloaddition of 2-alkynylaryl iso-thiocyanates and isonitriles in 2-methyltetrahydrofuran (2-MeTHF) to give a wide array of thieno[2,3-b]indoles in excellent yields. The reaction is featured by employing as little as 0.3 mol% nickel(II) acetylacetonate [Ni(acac) 2] under air conditions in the absence of any additives (additional reducing agents and external ligands). This is the first successful example to apply nickel(II) directly in hetero [2+2+1] cycloadditions.

• 出版日期2017-4-17
• 单位青岛科技大学