Asymmetric Synthesis of Tetrahydroquinolines through a [3+2] Cycloaddition Controlled by Dienamine Catalysis

作者：Li, Wenjun; Wei, Jia; Jia, Qianfa; Du, Zhiyun^*; Zhang, Kun; Wang, Jian

来源：Chemistry - A European Journal, 2014, 20(22): 6592-6596.

DOI：10.1002/chem.201402089

• asymmetric synthesis
• azomethine imines
• dienamines
• cycloaddition
• tetrahydroisoquinolines

A dienamine-mediated enantioselective 1,3-dipolar cycloaddition catalyzed by a chiral prolinol silyl ether catalyst has been developed. Removal of the benzamide group of the intermediates could furnish chiral C-1 substituted tetrahydroisoquinolines (see scheme) in high yields and excellent stereoselectivities.

• 出版日期2014-5-26
• 单位广东工业大学